How GnRH analogues are taken:

• Nafarelin acetate is sprayed into the nose (intranasally) 2 times a day.
• Cetrotide is injected under the skin 1 time daily for several days, or 1 time on day 7 of the menstrual cycle.
• Ganirelex is injected under the skin 1 time daily for several days.
• Leuprolide acetate (Lupron) is injected under the skin, while depo leuprolide acetate (Lupron Depot) is injected into a muscle. About 10 days of injections are typically necessary to "shut down" ovulation before stimulating ovulation for an infertility treatment.

About Ganirelix Acetate Injection

Ganirelix Acetate Injection is a gonadotropin-releasing hormone (GnRH) antagonist that is used to suppress premature luteinizing hormone (LH) surges in women during assisted reproductive technology (ART) treatment. This prevents eggs from being released prematurely.

Women who are using an injectable gonadotropin, such as Follistim^® AQ Cartridge (follitropin beta injection), may also be prescribed Ganirelix Acetate Injection because an injectable gonadotropin stimulates the growth of multiple follicles, which can cause an early rise in LH.

Like a GnRH agonist, Ganirelix Acetate Injection (an GnRH antagonist) is effective in preventing LH surges. Unlike a GnRH agonist, Ganirelix rapidly acts to prevent the LH surge after its initial injection.

The gonadotropin-releasing hormone (GnRH) antagonist Ganirelix Acetate Injection contains the active ingredient ganirelix acetate.

Ganirelix Acetate Injection is given on average five days mid-cycle gonadotropin stimulation. This translates to several benefits:

• Shorter treatment days.
• Lesser total medication is used.
• Fewer injections are needed.

Ganirelix Acetate Injection is the only GnRH antagonist in a ready-to-use pre-filled syringe, which means it is easy to administer because mixing isn't required. One pre-filled syringe of Ganirelix Acetate Injection contains 250 micrograms of ganirelix acetate. Ganirelix Acetate Injection can be stored at room temperature.

What is Cetrotide™
Cetrotide™ is a medication known as a gonadotropin-releasing hormone antagonist and is used to prevent premature ovulation in women undergoing fertility procedures.

What is Lupron®?
Lupron® is a gonadotropin-releasing hormone agonist. It inhibits the pituitary gland's ability to control the ovary and, therefore, is used to treat endometriosis. . In women with endometriosis, Lupron®? provides pain relief and reduction in the size of endometriosis lesions. The drug is also used as part of the process to stimulate multiple eggs for assisted reproductive technologies.